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Scientific Advisors’ Publications on CFS/ME

2013

Persistent human herpesvirus-6 infection in patients with an inherited form of the virus.

Journal of Medical Virology, 25 July 2013, doi: 10.1002/jmv.23685

Pantry, S. N., Medveczky, M. M., Arbuckle, J. H., Luka, J., Montoya, J. G., Hu, J., Renne, R., Peterson, D., Pritchett, J. C., Ablashi, D. V. and Medveczky, P. G. (2013)

Abstract: In conclusion, the data presented here document that some individuals with CIHHV-6 are infected persistently with exogenous HHV-6 strains that lead to a wide range of neurological symptoms; the proposed name for this condition is inherited herpesvirus 6 syndrome or IHS.

The adoption of chronic fatigue syndrome/myalgic encephalomyelitis case definitions to assess prevalence: a systematic review

Annals of Epidemiology Volume 23, Issue 6, Pages 371-376, June 2013

Abstract:  Prevalence estimates have been based on several case definitions of chronic fatigue syndrome (CFS). The purpose of this work is to provide a rigorous overview of their application in prevalence research. Read more

Enhanced Gene Expression Following Vaccination in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

International Journal of Clinical Medicine, 2013, 4, 165-170

Abstract:  The objective of this pilot study was to examine the consequences of TIV on cytokine and cytotoxic genes in CFS/ME. Read more.

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Parallels with Autoimmune Disorders

“Genes and Autoimmunity – Intracellular Signaling and Microbiome Contribution”, book edited by Spaska Angelova Stanilova, ISBN 978-953-51-1028-6, Published: March 13, 2013

Some unexplained disorders with immune compromises may demonstrate certain characteristics that suggest an autoimmune disorder including Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Read more here.

2012

A Double-Blind, Placebo-Controlled, Randomized, Clinical Trial of the TLR-3 Agonist Rintatolimod in Severe Cases of Chronic Fatigue Syndrome (Ampligen)

DOI: 10.1371/journal.pone.0031334   Published: March 14, 2012

A Phase III prospective, double-blind, randomized, placebo-controlled trial comparing twice weekly IV rintatolimod versus placebo was conducted in 234 subjects with long-standing, debilitating CFS/ME at 12 sites. Rintatolimod produced objective improvement in ET and a reduction in CFS/ME related concomitant medication usage as well as other secondary outcomes. Read more.

[PDF] The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Abstract: The purpose of this pilot study was to identify the effects of influenza vaccination on immune function in patients with CFS/ME.

Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis

Journal of Translational Medicine 2012, 10:88 doi:10.1186/1479-5876-10-88 9 May 2012

Abstract: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an etiologically unexplained disorder characterised by irregularities in various aspects of the immunological function. Presently, it is unknown whether these immunological changes remain consistent over time. This study investigates Natural Killer (NK) cell cytotoxic activity, NK cell subsets (CD56brightCD16- and CD56dimCD16+) and cytokines, over the course of a12 month period in patients with CFS/ME…Read more

A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

mBio 3 (5): eo266-12. doi:10.1128/mBio.oo266-12.Sept 18, 2012

Abstract: The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection.  Read more…

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Journal of Affective Disorders 2012 May 7. 7 May 2012

Abstract:  Immune dysfunction associated with a disease often has a molecular basis. A novel group of molecules known as microRNAs (miRNAs) have been associated with suppression of translational processes involved in cellular development and proliferation, protein secretion, apoptosis, immune function and inflammatory processes. MicroRNAs may be implicated in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), where immune function is impaired. The objective of this study was to determine the association between miRNAs in cytotoxic cells and CFS/ME… Read more

Simmaron News

Mason award landmark grant for CFS research

08 December 2011
Researchers at Bond University have received a landmark grant of over $800,000 to continue their ground-breaking research into identifying the cause and possible treatment of Chronic Fatigue Syndrome (CFS)…  Read more

Looking Forward: Dr. Peterson on ME/CFS Research, Treatment Options and Hope for the Future

22 October 2011
Dr. Dan Peterson and Dr. Cheney were the doctors on the scene as the most famous outbreak in chronic fatigue syndrome history took place in little Incline Village on the shores of Lake Tahoe high in the Sierra Nevada mountains in the early 1980’s.  Both caught ‘the bug’ and both have made CFS the focus of their careers…  Read more

 Ekua Brenu receives Junior Investigator Research Award for CFS/ME

20 October 2011
Bond University PhD student, Ekua Brenu, was recently awarded the Junior Investigator Research Award for Chronic Fatigue Syndrome from the International Association for Chronic Fatigue Syndrome/Myalgic Encepalomyelitis (IACFS/ME) in Ottawa, Canada….  Read more