Simmaron Laboratory

Mouse Models for ME/CFS: a drug-development must

Simmaron is starting animal research for drug discovery and molecular target identification. The new animal facility is located at the University of Wisconsin Milwaukee animal care facility. Transgenic and drug-induced mouse models to study autophagy impairment are underway.

Think about Parkinson's disease (PD), Alzheimer's disease (AD), and multiple sclerosis (MS). The phenomenal success over the years in these fields has been possible due to the availability of some reliable mouse models. Unfortunately, as of yet, there is no reliable mouse model that successfully achieves some pathological landmarks of ME/CFS such as post-exertional malaise (PEM) and orthostatic intolerance (OI).

Simmaron targets developing both drug-induced and genetic mouse models to study ME/CFS pathologies.